UGC Approved Journal no 63975(19)

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Published in:

Volume 6 Issue 6
June-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1908D79


Registration ID:
317865

Page Number

1408-1416

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Title

A STUDY OF SOLVENT EVAPORATION AND EXTRACTION IN MICROSPHERES FOR COLON TARGETING

Abstract

The treatment of colon cancer has been aimed by approaches of oral drug administration. 5-Fluorouracil is a candidate to be delivered orally to the colon; pH - sensitive polymers Eudragit S 100 and L 100 were used to prepare microspheres by a simple oil /water emulsification process. Process parameters were analyzed in order to optimize the drug loading and release profiles. In further attempts mixtures with Eudragit S100 and L100 were prepared to prolong drug release. Scanning electron microscopy permitted a structural analysis. The solvent extraction was preferable over solvent evaporation with a view to the encapsulation rate (extraction: 37%; evaporation: 19%) due to the hydrophilic character of the drug while release pattern were nearly unchanged. Eudragit S100, pure or in mixture, was found to retain drug release at pH 4.5 lower than 41% within 6 h. At pH 7.4, nearly immediate release (within 30 min) was observed for pure S100, while mixtures enabled to prolong the release slightly. Analysis of the morphology led to an inhomogeneous polymer distribution of S100 and L 100 throughout the particle core. However, the formulation proved its applicability in-vitro as a promising device for pH-dependent colon delivery of 5-fluorouracil. The study was aimed at develop the porous microspheres, which can control the drug release up to 6 h and hence it can prevent the acid decomposition in stomach.

Key Words

Colon delivery; colorectal cancer; Microspheres; 5-Fu.

Cite This Article

"A STUDY OF SOLVENT EVAPORATION AND EXTRACTION IN MICROSPHERES FOR COLON TARGETING", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 6, page no.1408-1416, June-2019, Available :http://www.jetir.org/papers/JETIR1908D79.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"A STUDY OF SOLVENT EVAPORATION AND EXTRACTION IN MICROSPHERES FOR COLON TARGETING", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 6, page no. pp1408-1416, June-2019, Available at : http://www.jetir.org/papers/JETIR1908D79.pdf

Publication Details

Published Paper ID: JETIR1908D79
Registration ID: 317865
Published In: Volume 6 | Issue 6 | Year June-2019
DOI (Digital Object Identifier):
Page No: 1408-1416
Country: Bhopal-Indore Road, MadhyaPradesh, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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