• MR. YADAV DINESH B
• MR. RANA HARSHRAJSINH A
• DR. MITTAL MAHESHWARI
• DR. PRAGNESH PATANI

In situ gel are viscous polymer-based liquid that exhibit sol-to-gel phase transition on the ocular surface due to change in specific physicochemical parameter like ionic strength, ph, or temperature. A major problem in ocular therapeutics is the attainment of optimal drug concentration at the site of action, which is compromised mainly due to pre-corneal loss resulting in only a small fraction of the drug being ocularly absorbed. The effective dose administered can be altered by prolonging the retention time of medication in to the eye by using in situ gel, thereby preventing the tear drainage. The object of the present study is to formulation and evaluation of the in situ ocular gelling system of ketorolac tromethamine. These gelling systems involve the use of gelrite as a polymer. The formulation was evaluated for clarity, ph measurement, gelling capacity, drug content estimation, rheological study, in vitro drug release, ocular irritancy studies (as per Draize test) and ex-vivo corneal permeation studies using isolated goat cornea. The developed formulation showed sustained release of drug for up to 6 hrs. the formulation was found to be non-irritating with no ocular damage. Various batches of ketorolac tromethamine bio adhesive in-situ gelling ocular inserts were prepared using sodium alginate and chitosan with glycerine as a plasticizer by solvent casting method. The formulated bio adhesive in-situ gelling ocular insert were then evaluated for physical appearance, thickness, weight variation, folding endurance, percentage moisture loss, percentage moisture absorption, tensile strength, percentage flatness, bio adhesive strength, force of adhesive, drug content, in vitro drug release, sterility test, in vitro antimicrobial efficacy, and stability study.

Bio adhesive in-situ gelling ocular inserts, chitosan, in vitro drug release, ketorolac tromethamine, sodium alginate, ketorolac tromethamine, Draize test, gelrite, ex-vivo corneal permeation studies, in situ gel.

"DEVELOPMENT AND ASSESSMENT OF NOVEL IN-SITU OCULAR GELS OF KETOROLAC TROMETHAMINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.1327-1337, February-2020, Available :http://www.jetir.org/papers/JETIR2002193.pdf

"DEVELOPMENT AND ASSESSMENT OF NOVEL IN-SITU OCULAR GELS OF KETOROLAC TROMETHAMINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp1327-1337, February-2020, Available at : http://www.jetir.org/papers/JETIR2002193.pdf