• Bindu C
• Rama Bhat P
• Mahesh Kumar K S

Abstract: Diabetes mellitus is known to affect many and varied parameters in rat liver. Insulin, biguanides and sulphonylureas are known anti-diabetic diabetic treatments. In this study, Costus speciosus extract was tested for its effect on liver microsomes of streptozotocin induced diabetic rats. In particular the changes in the enzyme activities of cytochrome P-450 (2E1, 2B and 2C) on androst-4-ene-3,17-dione metabolism reversal. Metabolism of endogenous substrates, as well as exogenous xenobiotic is crucially mediated by Cytochrome P-450. The in-vivo effects of C. specious extract on internal parameters like enzymatic activities of cytochrome P-450 using separated microsomes from liver was estimated. The administration of streptozotocin caused a significant increase (p<0.01) in the enzyme activity of liver microsomes.

Diabetes, Costus speciosus, cytochrome P-450

"Assessment of cytochrome P- 450 enzyme activity in diabetic rat treated with Costus speciosus (Koen Ex. Retz) smith plant extract", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 2, page no.355-357, February-2020, Available :http://www.jetir.org/papers/JETIR2002254.pdf

"Assessment of cytochrome P- 450 enzyme activity in diabetic rat treated with Costus speciosus (Koen Ex. Retz) smith plant extract", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 2, page no. pp355-357, February-2020, Available at : http://www.jetir.org/papers/JETIR2002254.pdf