• Dipak Bhargava
• Anisha Kumari
• R. Paudyal

ABSTRACT Introduction: Neonatal sepsis continues to be a major cause of neonatal mortality and morbidity. A very wide spectrum of organisms and their susceptibility pattern has been described for cases of neonatal sepsis and these spectrums is subject to geographical alterations. Material and Methods: A prospective hospital based study was carried out with the objective to study the etiological agents of neonatal sepsis and their antibiogram pattern. Blood culture was performed from all the suspected cases of neonatal sepsis from National Medical College and Teaching Hospital. Antibiotic susceptibility test, ESBL test and Methicillin-resistance test were performed according CLSI guidelines (2014). SPSS version 19 software was used for data analysis. Results: In total 255 blood samples were studied, out of which 79 (31%) were culture positive. The organisms isolated were Staphylococcus aureus followed by CONS and Enterococcus faecalis. The most common risk factors associated with neonatal sepsis were low birth weight and preterm delivery, whereas clinical features were fever, respiratory distress and seizure. Meropenem, levofloxacin and amikacin was found most effective antibiotic against all isolates. Among total isolates 89.9% (71/79) multi drug resistant organisms were isolated. Among Gram-negative pathogen, 68.5% (13/19) were ESBL producers and among Gram-positive, 77.3% (34/44) Staphylococcus species were methicillin resistant. Conclusion: Staphylococcal sepsis is common in both community and hospital acquired sepsis. The multidrug resistant strains make the treatment difficult and grave sequel. Knowledge of sensitivity patterns is essential when local polices on the uses of antibiotics are being devised. Keywords: Antibiogram pattern, Bacteriological profile, Neonatal sepsis

Antibiogram pattern, Bacteriological profile, Neonatal sepsis

"BACTERIOLOGICAL PROFILE OF NEONATAL SEPSIS AND ANTIBIOGRAM PATTERN OF THE ISOLATES IN NATIONAL MEDICAL COLLEGE AND TEACHING HOSPITAL, BIRGUNJ.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 3, page no.288-297, March-2020, Available :http://www.jetir.org/papers/JETIR2003345.pdf

"BACTERIOLOGICAL PROFILE OF NEONATAL SEPSIS AND ANTIBIOGRAM PATTERN OF THE ISOLATES IN NATIONAL MEDICAL COLLEGE AND TEACHING HOSPITAL, BIRGUNJ.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 3, page no. pp288-297, March-2020, Available at : http://www.jetir.org/papers/JETIR2003345.pdf