• Pramod B. Thakur

In the current manuscript demonstrates biodegradable deep eutectic solvent ([Ch][Cl]-Urea) mediated Henry reaction of a variety of isatins with nitroalkanes at room temperature to afford, 3-hydroxy-3-(nitroalkyl)-oxindoles in very good yields. The developed reaction is found general which tolerated variety of functional groups like alkyl, phenyl and halides. Furthermore the developed method is column chromatography free protocol which has afforded sufficiently pure compounds just by filtration process without employing aqueous work-up extraction step. Moreover the high diastereoselectivity can also be achieved without using catalyst or chiral mediator. Wide scope of substrates with high yields and mild reaction condition are the notable features of our protocol. The developed method may be useful in the synthesis of new natural products and biologically important 3-hydroxy oxindole analogues under mild reaction conditions

DES; Henry Reaction; Isatin; Nitroalkane; Oxindole; Green Chemistry

"Exploration of Biodegradable Deep Eutectic Solvent in the Henry Reaction to afford 3-Hydroxy Oxindole Scaffolds", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 4, page no.259-263, April-2020, Available :http://www.jetir.org/papers/JETIR2004036.pdf

"Exploration of Biodegradable Deep Eutectic Solvent in the Henry Reaction to afford 3-Hydroxy Oxindole Scaffolds", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 4, page no. pp259-263, April-2020, Available at : http://www.jetir.org/papers/JETIR2004036.pdf