• Santoshi Madhukarrao Deshmukh
• Abhijit Kulkarni
• Shubhada Bhausaheb Dube
• Vitthal Sahebrao Gunjal
• Pankaj Kailas Deshmukh

Silymarin is flavonoid obtained from Silybum marianum plant. It is used as hepatoprotective, antioxidant, anti-inflammatory, hypolipidemic, and anti-carcinogenic properties[44]. Silymarin is BSC II class drug contains eight flavonolignans which having poor aqueous solubility due to this it rapidly excreted in bile and urine and poor bioavailability of these flavonolignans after oral route administration due to phase II metabolism, therefore in this review a potential approach to enhance solubility, bioavailability and to develop a robust formulation and scientific aspects from past to present is studied . In cancer treatment Nanomaterials are frequently used as drug carriers [12]. There is a need to have a selective and accurate analytical method for qualitative and quantitative estimation of silymarin flavonolignan elements[a]. Silymarin containing products have an important role in the quality control of milk thistle-based products. Due to the low concentrations of analytes, especially pharmacological and pharmacokinetic studies require more and more selective and sensitive, advanced techniques [N]. Therefore, the scope of this review was to develop a better understanding of the problems associated with silymarin and approaches to overcome the difficulties to develop a better and stable formulation for food and pharmaceutical applications.

silymarin, hyphenated techniques, formulation, pharmacological activity.

"Silymarin: Review on overall developed formulations and analytical methods", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 5, page no.56-63, May-2020, Available :http://www.jetir.org/papers/JETIR2005150.pdf

"Silymarin: Review on overall developed formulations and analytical methods", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 5, page no. pp56-63, May-2020, Available at : http://www.jetir.org/papers/JETIR2005150.pdf