• Handri R Vebrian
• Muhammad Fidel Ganis Siregar

ABSTRACT The most common and disturbing symptom of menopause is a hot flash. One of the substances that is thought to play a role in hot flashes is leptin. Leptin functions to maintain energy balance in the body. Estrogen has the effect of increasing the sensitivity of leptin in the brain so that in the menopausal state where estrogen deficiency occurs, it causes leptin sensitivity to decrease which will eventually increase leptin levels. This study is an analytic study with Case Control design by examining women in H. Adam Malik General Hospital Medan at November - December 2019 to see the correlation between serum levels of leptin and estradiol with the presence of hot flashes and without hot flashes in menopausal women. The sample of this study is 50 people by consecutive sampling. Serum levels of leptin and estradiol are examined by conducting laboratory tests on venous blood using the ELISA (Enzyme Linked Immunosorbent Assay) method. Then data is collected and analyzed using statistical analysis. There was a significant difference in serum leptin levels in menopausal women with symptoms of hot flash (25,87 ± 1.23) and without hot flash (23.86 ± 0.75) (p <0.001). Mean of estradiol level in hot flashes group (25.52 ± 2.85) and without hot flash group (26.12 ± 1.45) there was no significant differences in serum estradiol levels in menopausal women with or without symptoms of hot flash (p = .922). Correlation was obtained between serum leptin and estradiol levels in the event of hot flash -0.294 (p = 0.154) which indicates a negative correlation with a weak strength between serum leptin level and estradiol level in menopausal women with symptoms of hot flash. This suggests that the higher the leptin, the lower the estradiol levels. Keywords : Leptin Serum, Estradiol, Hot Flash, Menopause

Keywords : Leptin Serum, Estradiol, Hot Flash, Menopause

"Correlation Between Leptin and Estradiol Serum Level to Hot Flashes on Menopause Woman", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 7, page no.1057-1064, July-2020, Available :http://www.jetir.org/papers/JETIR2007132.pdf

"Correlation Between Leptin and Estradiol Serum Level to Hot Flashes on Menopause Woman", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 7, page no. pp1057-1064, July-2020, Available at : http://www.jetir.org/papers/JETIR2007132.pdf