• R.SATHYA
• A.XAVIER

Abstract: Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. A novel schiffbase ligand is synthesized by Ketone with Aromatic Amine to form a Schiffbase ligand (L). It is mixed with 1stRow transition metal ions to form metal complexes. Complexes are characterized by Elemental analysis, UV- spectroscopy, Infrared spectroscopy and H1 NMR, C13 NMR spectroscopy. Elemental analysis of the metal complexes was suggested that the stoichiometry ratio is 1:2 (metal-ligand). The UV spectrum gives clear idea about the metal complexes. Fluorescence studies of ligand and complexes also performed. The Schiff base complexes have been screened for their invitro antibacterial activity against three bacteria via; (Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus sp.) also studied antifungal activities (Aspergillus Niger and Aspergillus flavus). Anti-oxidant properties of metal complexes also have been studied.

Keywords: Schiff base, Transition metal complexes, spectroscopy, Fluorescent analysis, Biological activity, Anti-oxidant study.

"Biological accomplishments of Transition metal complexes incorporating novel Schiff base ligand 2-(1-(3-aminopropylimino) ethyl) phenol).", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 8, page no.393-405, August-2020, Available :http://www.jetir.org/papers/JETIR2008050.pdf

"Biological accomplishments of Transition metal complexes incorporating novel Schiff base ligand 2-(1-(3-aminopropylimino) ethyl) phenol).", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 8, page no. pp393-405, August-2020, Available at : http://www.jetir.org/papers/JETIR2008050.pdf