• CHANDRAMA DHERANGE
• KANCHAN CHAUHAN

A new simple, precise, selective, accurate and rapid reverse phase high performance liquid chromatographic method has been developed and validated for drugdolutegravir in bulk and pharmaceutical dosage form. The column used for development was IntersilC-18, ODS-3, 5µm 4.6×250mm particle size and the mobile phase used aspH 3.6Phosphate buffer: Acetonitrile in ratio of (40:60) v/v with flow rate of 1ml/min. The wavelength used for detection was 258 nm. The limit of detection and limit of quantification was found to be 2.70 and 8.19 µg / mlwhich demonstrated that the method is sensitive. The method was found to be linear and correlation coefficient obtained was 0.9996.The system suitability parameters were found to be within the limits.

Dolutegravir, high performance liquid chromatography

"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DOLUTEGRAVIR IN BULK AND SOLID DOSAGE FORM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 9, page no.811-816, September 2020, Available :http://www.jetir.org/papers/JETIR2009409.pdf

"DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR DOLUTEGRAVIR IN BULK AND SOLID DOSAGE FORM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 9, page no. pp811-816, September 2020, Available at : http://www.jetir.org/papers/JETIR2009409.pdf