• PRIYANKA CHATURVEDI
• MANISH SHARMA

In recent decades, extensive research has been conducted to develop a floating gastroretentive drug delivery (FGRDD).Gastroretentive drug delivery systems are a good example; have emerged to increase the bioavailability and efficacy of drugs with a narrow absorption window in the upper gastrointestinal tract and / or to promote local stomach and duodenal activity. drugs that are locally active in the stomach and upper intestine because FGRDD allows the drug to stay in the stomach for a longer period of time. these types of systems have both advantages and disadvantages. Intraindividual and differences in gastric physiology are obstacles to the development of efficient FGRDD. These include gastric pH and gastric motility, which have a significant impact on gastric retention time. Some of these obstacles can be overcome by developing a new floating drug delivery system. In this review, research and development of speed-controlled floating release systems overcoming physiological adversities, such as short gastric residence times (GRT) and unpredictable gastric emptying times (GET).

Floating gastroretentive drug delivery, gastric motility, gastroretentive narrow absorption window, controlled drug release, gastro retentive system, gastric retention time

"OVERVIEW ON FLOATING GASTRORETENTIVE DRUG DELIVERY SYSTEMS FOR IMPROVING ORAL BIOAVAILABILITY OF DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.7, Issue 11, page no.272-279, November-2020, Available :http://www.jetir.org/papers/JETIR2011043.pdf

"OVERVIEW ON FLOATING GASTRORETENTIVE DRUG DELIVERY SYSTEMS FOR IMPROVING ORAL BIOAVAILABILITY OF DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.7, Issue 11, page no. pp272-279, November-2020, Available at : http://www.jetir.org/papers/JETIR2011043.pdf