• Dr.J.kamakshamma
• N Santaiah

The present study evaluated the anti-hyperglycemic activity of the Ethyl acetate extract of Acanthospermum hispidum on blood glucose, Plasma insulin and glycoprotein contents of albino rats. AHEt was administered at doses of 150, 300 and 450 mg/kg body weight respectively on stz induced diabetic rats for 2 weeks. The aim of this study was to investigate the effect of ethanolic extract of Acanthospermum hispidum (AHEt) in stz induced diabetic, which was induced in male albino Wistar rats by a single intra peritoneal injection of streptozotocin (55 mg/kg). After injection, the animals were divided into five groups viz., control group, AHEt (300mg/kg) treated group, diabetic group, diabetic + AHEt (450mg/kg) body weight for 2 weeks .The study shows a significant increase in the levels of blood glucose, and plasma glycoproteins, while plasma insulin levels were significantly decreased in diabetic rats. There was also a significant decrease in the level of sialic acid and elevated levels of hexose, hexosamine in the liver and kidney of diabetic rats. The diabetic animals also showed a reduction of body weights. Oral administration of AHEt reverted these changes. Thus the study indicates that Acanthospermum hispidum. possesses a significant beneficial effect on glycoprotein's in addition to its antidiabetic action.

hypoglycemic activity, Acanthospermum hispidum, Ethyl acetate extract

"Effect of Aqueous and ethyl acetate extracts of Acanthospermum hispidum on Streptozotocin induced diabetic animals", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 7, page no.c614-c617, July-2021, Available :http://www.jetir.org/papers/JETIR2107349.pdf

"Effect of Aqueous and ethyl acetate extracts of Acanthospermum hispidum on Streptozotocin induced diabetic animals", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 7, page no. ppc614-c617, July-2021, Available at : http://www.jetir.org/papers/JETIR2107349.pdf