• Ankita Pokhriyal
• Pranshu Tangri

The aim of present study deals with the Design and evaluation of oral fast dissolving thin strips loaded with Donepezil hydrochloride. Donepezil HCl is a specific noncompetitive reversible inhibitor of acetyl cholinesterase (AChE) used in the treatment of Alzhiemer’s disease. Films were formulated using film forming polymer like Sodium alginate, Pectin, Polyvinyl alcohol by Solvent casting technique. The films were evaluated for weight variation, thickness, surface pH, folding endurance, drug content, disintegration time, moisture content, moisture uptake, tensile strength, vapour transmission rate, in-vitro dissolution studies by pharmaceutical standard methods. Based on the evaluation parameters optimized strips were formulated. The optimized strips were kept for accelerated stability studies as per ICH guidelines (Zone IV) at 45C & 75% relative humidity. It was found that there was not any substantial interactions between drug content and the prepared formulations were stable. Among the formulations FV1 and FC2 were found to be best based on evaluation parameters and stability studies. After performing stability study it was observed that at accelerated conditions 40˚ ± 2˚C and 75 % ± 5 % RH there was no change in % drug content of the formulation FV1 and FC2. At zero day the drug content for formulation FV1 and FC2 was found to be 97.5±0.25 and 98±0.02 respectively and after 1 month it was95.8±0.23 % and 96.9±0.03 %.for formulation FV1 and FC2 respectively.

Oral fast dissolving strips, Donepezil HCl, Alzheimer’s

"Design and evaluation of oral fast dissolving thin strips loaded with Donepezil hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.8, Issue 9, page no.e671-e685, September-2021, Available :http://www.jetir.org/papers/JETIR2109482.pdf

"Design and evaluation of oral fast dissolving thin strips loaded with Donepezil hydrochloride", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.8, Issue 9, page no. ppe671-e685, September-2021, Available at : http://www.jetir.org/papers/JETIR2109482.pdf