• VINITA KUKREJA
• Dr. Uma Kumari

Cancer, one of the leading causes of deaths globally, in which majority of central nervous system (CNS) tumors are originates from glial cells leading to gliomas. Glioblastoma Multiforme (GBM) is an aggressive type tumor, arise from astrocytes cells. GBMs are classified into primary and secondary, these alters the core signaling pathways inducing cell proliferation and intensifying cell survival. To analyse structure properties domain and function of GBM, we examined the protein that has major role in the therapy resistance. Using computational approach we were able understand the molecular interaction between receptor and ligand. Graphical representation shows the similarities between query and database sequence. Using molecular graphic program we visualize our target protein in different form shapely, structure, spacefill which includes amino acid residues, protein secondary structure and size dependent atoms respectively. Molecular Docking of target protein determines the conformation and binding energy between ligand and receptor. Bioinformatics and virtual screening methods to help in identify drugs that can bind to specific targets, so as to promote the research and development of brain cancer drugs.

Brain tumor, glioma, gene, targeted therapy, precision medicine, Docking, Structure Analysis, Panorama view.

"Genome Annotation of Brain Cancer and Structure Analysis by applying Drug Designing Technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 5, page no.k473-k479, May-2022, Available :http://www.jetir.org/papers/JETIR2205B62.pdf

"Genome Annotation of Brain Cancer and Structure Analysis by applying Drug Designing Technique", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 5, page no. ppk473-k479, May-2022, Available at : http://www.jetir.org/papers/JETIR2205B62.pdf