• Priyanka M. Dahekar
• Dr. R. B. Wakade

The purpose of the present study was to enhance the solubility of poorly water soluble drug, Repaglinide using spray drying based on solid dispersion technique by using the hydrophilic carrier Polyethylene glycol 4000 (PEG 4000) in three different drug: PEG 4000 ratios ( 1:1, 1:3, 1:5), with the addition of Aerosil 200. The batch with drug-carrier ratio 1:5 was found to be an optimized batch. The formulations were characterized by Fourier transformed infrared spectroscopy (FT-IR Spectroscopy), and X-ray diffractometry (XRD). Dissolution studies were carried out in pH 7.4 Phosphate buffer. SDSD was also evaluated for its Physical characteristics, percentage yield, flow properties and particle size determination. Stability study of selected optimized formulation was carried out by storing at 40˚C /75% RH for 1 month. The FT-IR studies revealed that, no drug- excepient interaction takes place. From powder X-ray diffraction study it was found that crystalline form of Repaglinide has been converted into an amorphous form in the solid dispersion formulations. Rapid burst release (80-82% ) from the solid dispersion formulation was observed within 60 min. From the obtained results it was concluded that, developed solid dispersion is an effective approach for enhancing the solubility and hence dissolution rate of the Repaglinide.

Diabetes mellitus, Repaglinide, PEG 4000, Solid dispersion, spray drying.

"DEVELOPMENT AND EVALUATION OF SOLID DISPERSION OF POORLY WATER SOLUBLE DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 6, page no.i418-i429, June-2022, Available :http://www.jetir.org/papers/JETIR2206851.pdf

"DEVELOPMENT AND EVALUATION OF SOLID DISPERSION OF POORLY WATER SOLUBLE DRUG", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 6, page no. ppi418-i429, June-2022, Available at : http://www.jetir.org/papers/JETIR2206851.pdf