• Akanksha Jethmal
• Ravikant Gupta

To overcome drawbacks associated with conventional drug delivery of ketoconazole an attempt is being made to design an alternative drug delivery system in form of Proniosomes. They minimize problems of niosome physical stability such as aggregation, fusion, leaking and provide additional convenience in transporation, distribution, storage and dosing both phospholipids and non ionic surfactants in proniosomes can act as penetration enhancers and help in diffusion of the drug .Proniosomes also avoid problems associated with liposomes like degradation by hydrolysis or oxidation as well as sedimentation, aggregation or fusion during storage. Therefore, it is envisaged to prepare proniosomes of ketoconazole for the attainment of better therapeutics in candidiasis. The drug is 99% protein bound moreover, it is hepatotoxic hence a cutaneous/topical delivery is more beneficial for the attainment of better therapeutic results. To overcome the side effects associated with conventional delivery and formulation is envisaged for the drug. Prepared proniosome shall penetrate deeper in the skin and led to better and faster therapeutics effect as compared to conventional formulation. In the present study, the slurry method was used for the preparation and optimization of ketoconazole proniosomes formulation. KEYWORDS: Ketoconazole, Proniosomes

Ketoconazole, Proniosomes

"FORMULATION & CHARACTERIZATION OF KETOCONAZOLE PRONIOSOMES FOR THE TREATMENT OF CANDIDIASIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.b20-b43, July-2022, Available :http://www.jetir.org/papers/JETIR2207102.pdf

"FORMULATION & CHARACTERIZATION OF KETOCONAZOLE PRONIOSOMES FOR THE TREATMENT OF CANDIDIASIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppb20-b43, July-2022, Available at : http://www.jetir.org/papers/JETIR2207102.pdf