• Mahendra A. Giri
• K. Vanitha Prakash
• Sanjay B. Kasture

Context: Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting about 1.5% of the global population over 65 years of age. Oxidative stress plays an important role in the pathogenesis of neurodegeneration. Withania somnifera and Camellia sinensis are traditional herbs known to have neuroprotective and antioxidant effects. In the present study, comparative antiparkinsonian effect of hydroalcoholic extract of Camellia sinensis leaves (HECS) and Withania somnifera roots (HEWS) on 6-OHDA-Lesioned Rat Model was studied and this experiment evaluated the effect on the hemiparkinsonism induced in rats. The results were analyzed by repeated measure ANOVA followed by Dunnett's test. In this study, the selected doses of HEWS and HECS & their MIXTURE in equal parts at 30mg/kg &100mg/kg exhibited neuroprotective effect. These treatments increased contralateral turing behaviour indicative of antiparkinsonian activity.

Antiparkinsonian, Haloperidol, Reserpine, Tacrine, Withania somnifera, Camellia sinensis

"NEUROPROTECTIVE EFFECTS OF Withania somnifera AND Camellia sinensis ON 6-OHDA-LESIONED RAT MODEL OF PARKINSON’S DISEASE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.b264-b275, July-2022, Available :http://www.jetir.org/papers/JETIR2207130.pdf

"NEUROPROTECTIVE EFFECTS OF Withania somnifera AND Camellia sinensis ON 6-OHDA-LESIONED RAT MODEL OF PARKINSON’S DISEASE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppb264-b275, July-2022, Available at : http://www.jetir.org/papers/JETIR2207130.pdf