• M.E.Rani
• A.Jayaraju

Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations ofblood-brain barrier (BBB) which is a selective interface that excludes most water-soluble moleculesfrom entering the brain. Neutral amino acids permeate the BBB by specific transport systems. Condensationof dopamine with neutral amino acids could afford potential prodrugs able to interact with theBBB endogenous transporters and easily enter the brain. The synthesis and characterization of thedopamine derivative4-(2-Aminoethyl)benzene-1,2-diol Carbamodithiolatessynthesized from Dopamine and Carbon disulfide and further characterized. Docking studies showed that blocking the division of cancer cells and resulting in cell death. It is necessary to understand the binding properties in developing new potential Protein targeting against neurological disorders.

Dopamine, Docking Studies, Carbamodithiolates, neurological disorders.

"SYNTHESIS, MOLECULAR DOCKING AND BIOLOGICAL EVALUATION OF DOPAMINE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 7, page no.g501-g508, July-2022, Available :http://www.jetir.org/papers/JETIR2207671.pdf

"SYNTHESIS, MOLECULAR DOCKING AND BIOLOGICAL EVALUATION OF DOPAMINE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 7, page no. ppg501-g508, July-2022, Available at : http://www.jetir.org/papers/JETIR2207671.pdf