• Zabin Begum Khoje
• Muniswamy David

The increase in use of pesticide in agriculture over the recent years have posed serious health concerns in non-target organisms including humans. As the exposure to humans through various means is inevitable by various means, their regulation and evaluation of toxic impact has become the need of the hour. The carbamate pesticide carbofuran, although has a reversible acetylcholine esterase inhibition property, in long-term exposure the effects are more harmful as reported earlier. Our study deals with intragastric exposure of carbofuran to male wistar albino rats (Rattus norvegicus) in dose and duration dependent manner emphasizing the role of serum biomarkers for homeostasis disruption in liver. We observed significant alterations(p<0.05) in total, direct and indirect bilirubin levels, liver transaminases including alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels. The total protein, albumin and globulin levels along with albumin to globulin ratio was also hampered upon long-term exposure. The present study provides an approach for evaluation of serum biomarkers at initial toxicity assessment which not only provides information about homeostasis disruption but also an insight into underlying mechanisms of alteration.

Carbofuran, Liver function tests, serum proteins.

"Carbofuran Induced Dose and Duration Dependent Alterations in Serum Biomarkers in Male Wistar Albino Rats (Rattus norvegicus)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 9, page no.b630-b638, September-2022, Available :http://www.jetir.org/papers/JETIR2209177.pdf

"Carbofuran Induced Dose and Duration Dependent Alterations in Serum Biomarkers in Male Wistar Albino Rats (Rattus norvegicus)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 9, page no. ppb630-b638, September-2022, Available at : http://www.jetir.org/papers/JETIR2209177.pdf