• Trunali Ghude
• Sanket Dharashivkar
• Madhuri Gaikwad
• Pritam Juvatkar

The aim of this investigation was to develop and optimize Pirfenidone matrix tablets for sustained release application by using response surface methodology based on 32 factorial design. Pirfenidone is a drug that is used to treat idiopathic pulmonary fibrosis (IPF). The effects of the amounts of Ethyl Cellulose (X1) and Kollidon SR (X2) were chosen as independent variables and the % drug release after 2 hours (Y1) and % drug release after 8 hours (Y2) were analyzed and optimized. The observed responses were coincided well with the predicted values by the experimental design. Initially, drug-excipients compatibility studies were carried out by using Differential Scanning Calorimetry (DSC) which indicated no interaction between drug and excipients. In vitro drug release study revealed that as the amount of polymers increased, % drug release decreased. These matrix tablets followed Korsemayer –Peppas model with anomalous (non-Fickian) diffusion mechanism. The optimized Pirfenidone matrix tablets demonstrated prolonged sustained release of Pirfenidone over 8 hours.

Pirfenidone, direct compression, Sustained release, Optimization, response surface methodology, Factorial design

"FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF PIRFENIDONE USING 3² FULL FACTORIAL DESIGN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 10, page no.b348-b363, October-2022, Available :http://www.jetir.org/papers/JETIR2210155.pdf

"FORMULATION AND OPTIMIZATION OF SUSTAINED RELEASE MATRIX TABLETS OF PIRFENIDONE USING 3² FULL FACTORIAL DESIGN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 10, page no. ppb348-b363, October-2022, Available at : http://www.jetir.org/papers/JETIR2210155.pdf