• Apurva Sunil Belsarkar
• Ajay D Shinde

Abstract: The drug Carbamazepine, a dibenzazepine derivative, is used to treat a variety of disorders, including epilepsy, trigeminal neuralgia, and bipolar disorder. Carbamazepine is the most effective and affordable first-line medication for seizures. The biopharmaceutical classification system classifies Carbamazepine as BCS class II drug because of their strong membrane permeability and poor water solubility, which make dissolution the rate-limiting stage in the absorption process. By considering it formulation was designed and polymorphic alterations of the drug Carbamazepine are evaluated in its tablet dosage form. A differential scanning colorimetric study was carried out for a tablet formulation of Carbamazepine to identify the polymorphic changes in the drug. The basic goal of study to investigate the impact of Carbamazepine Matrix tablet design by utlizing lyophilization technique on the drug Carbamazepine for specific polymorphic modifications in designed tablet dose form.

Key words: Carbamazepine, Polymorphism, DSC, Lyophilization, Epilepsy, Tablet.

"'Study of Formulation and Development of Carbamazepine in Matrix Tablet for Polymorphism'", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 10, page no.c173-c183, October-2022, Available :http://www.jetir.org/papers/JETIR2210221.pdf

"'Study of Formulation and Development of Carbamazepine in Matrix Tablet for Polymorphism'", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 10, page no. ppc173-c183, October-2022, Available at : http://www.jetir.org/papers/JETIR2210221.pdf