• Shahid ali
• Mohd Qamar
• Ms Shivali Sagar

For controlled administration of diclofenac sodium to the skin in this investigation, ethyl cellulose-facilitated microsponges were created using the two fold emulsification approach (also known as the quasi emulsion technique). By using ethyl cellulose as a polymer and a quasiemulsion solvent diffusion technique, the microsponges formulations were created. Fourier Transform Infra-Red (FTIR) spectroscopy was used to determine the drug's compatibility with formulation ingredients. We looked at the microsponges' surface shape, particle size, production yield, and drug entrapment effectiveness. Using scanning electron microscopy, the microsponges' shape and surface morphology were studied. The porous, spherical form of the microsponges was discovered using scanning electron microscopy.In all variations, SEM images showed that the microsponges were spherical; however, at larger ratios, drug crystals were seen on the microsponge surface. Consequently, though in ascending sequence due to the rise in polymer concentration, beyond a certain concentration, it was noticed that when the ratio of drug to polymer rose, the particle size. The gel's pH was determined to have an average pH. The drug content of various formulations, the spreadibility of gel-containing microsponges, exhibiting good spreading characteristics, and the cumulative release of the formulations. The viscosity of the formulation was analysed by Brookfield viscometer.

: Quasi Emulsion Technique, Sodium Diclofenac, Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), Microsponge Delivery System (MDS).

"Microsponges of sodium diclofenac", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.d100-d104, November-2022, Available :http://www.jetir.org/papers/JETIR2211314.pdf

"Microsponges of sodium diclofenac", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppd100-d104, November-2022, Available at : http://www.jetir.org/papers/JETIR2211314.pdf