• M Satya Prasad
• A. Krishna Satya

Diabetes mellitus is a multi-etiology metabolic disorder in which chronic hyperglycemia is caused by deficiencies or changes in either insulin discharge or behaviour resulting in disruptions in the metabolism of carbohydrates, fats and proteins. Medicinal plants are rich in bioactive compounds, making them an important raw material for drug production and a target for the quest for new drugs. To evaluate the anti-diabetic activity of the P.korintii leaves and bark, the extracts were tested. The results of the α- amylase inhibition and α-glucosidase inhibition activities showed that all the extracts of Polyalthia korinti leaves and bark showed a varying effect on glucose utilization. Out of all the extracts Methanol extract of leaves showed the lowest IC50 value. The lowest IC50 indicates the strongest ability of the extracts to act as an amylase and α - glucosidase inhibitory activity. The glucose transfer across the yeast cell membrane was enhanced by all sample extracts. When glucose uptake by yeast cells was compared at 5 mM, 10 mM, and 20 mM for the same amount of plant extract, an inverse relationship to the molar concentration of glucose was observed. Out of all the extracts methanol extracts have great potential as antidiabetic. The results can be used to guide future research into how to prepare and optimize plant extracts for structural elucidation and characterization methodologies to identify anti-diabetic bioactive compounds.

Diabetic mellitus, Polyalthia korinti , α- amylase inhibition, α -glucosidase inhibition, glucose uptake.

"IN VITRO EVALUATION OF ANTI-DIABETIC ACTIVITY OF POLYALTHIA KORINTI EXTRACTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 11, page no.e425-e433, November-2022, Available :http://www.jetir.org/papers/JETIR2211471.pdf

"IN VITRO EVALUATION OF ANTI-DIABETIC ACTIVITY OF POLYALTHIA KORINTI EXTRACTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 11, page no. ppe425-e433, November-2022, Available at : http://www.jetir.org/papers/JETIR2211471.pdf