• MOHD AYYUB
• Mohd Qamar
• MS Shivali Sagar

Aspirin is a nonsteroidal anti-inflammatory medication (NSAID). . Easily absorbed from the digestive system is aspirin. Aspirin functions in a manner similar to other NSAIDs but also inhibits platelet activity normally. To create acetylsalicylic acid for the first time, scientist Charles Frédéric Gerhardt combined sodium salicylate with acetyl chloride in 1853. Formulations with improved physicochemical qualities is a difficult issue for pharmaceutical researchers and industry. Acetylsalicylic Acid, better known as aspirin, In solutions of ammonium acetate or the acetates, carbonates, citrates, or hydroxides of the alkali metals, aspirin decomposes very quickly. We constructed two-phase enteric-coated granules of aspirin and L-glutamate compound by extrusion spheronization method and fluidized bed coating. Aspirin is classified as a bcs classification ii tablet, which are solid dosage forms manufactured by compression and containing one or more medicines with or without excipients. It offers the least content fluctuation and good dosage accuracy. Tablet additives refer to inert substances used in addition to active components.This aspirin product is collected, refined by recrystallization, and its purity is assessed by measuring its melting temperature. Utilizing a Büchner filtration device, separate the crystals from the liquid while completely removing the aspirin from the flask using tiny amounts of the ice-cold deionized water. The monsanto hardness test equipment was used to measure the hardness of the tablets. Instead, we switched to another piece of equipment and discovered that salicylic acid, which has a molecular weight of 0.330 g, was synthesised by reacting excessively with acetic amhydride. The amount of aspirin product that is theoretically feasible is determined by the amount of salicylic acid utilised because too much aceticanhydride was used. The molecular weight of aspirin is 0.635 g.

ASPIRIN, ACETYLSALICYCLIC ACID, NON INFLAMMATORY DRUG, ACETIC ACID.

"preparation and evalution of aspirin ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 12, page no.a443-a450, December-2022, Available :http://www.jetir.org/papers/JETIR2212051.pdf

"preparation and evalution of aspirin ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 12, page no. ppa443-a450, December-2022, Available at : http://www.jetir.org/papers/JETIR2212051.pdf