• shalinee soni
• dr lokesh verma

Nicotine, the psychoactive component of tobacco, is commonly used by humans due to its addictive propensity. Nociception (sometimes nocioception or nociperception) is the nervous system's encoding and processing of noxious stimuli. For a long time, central serotonergic pathways have been linked to antinociception mechanisms. Locomotor activity will be represented as the total number of locomotor counts for each light beam disrupted in the past six minutes of testing. After each test, the arena will be cleaned with damp cotton soaked in alcohol before exposing the next treated animal. In behavioral and electrophysiological paradigms, there is evidence for both pronociceptive and antinociceptive effects of 5-HT, which are mediated by different 5-HT receptor subtypes. In this research, we will explore the effect of a serotonergic analogue on nicotine tolerance, antinociceptive effect, and withdrawal-induced hyperalgesia. The current study aims to elucidate the function of seretonergic transmission in nicotine's diverse reinforcing effects. As a result, we will be attempting to shed new light on the probable mechanisms of nicotine-induced effects such as antinociception and hyperalgesia.

Nicotine, Antinociceptive effect, Hyperalgesia, Nociception, Nocioception.

"Nicotine-induced Nicotinic receptor upregulation and the involvement of the role of central serotonergic transmission", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 12, page no.d383-d398, December-2022, Available :http://www.jetir.org/papers/JETIR2212353.pdf

"Nicotine-induced Nicotinic receptor upregulation and the involvement of the role of central serotonergic transmission", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 12, page no. ppd383-d398, December-2022, Available at : http://www.jetir.org/papers/JETIR2212353.pdf