• Dr. Tshetiz Dahal
• Dr. Jeby Abraham
• Dr. Jainy Abraham

Background: High blood pressure is a major risk factor for cardiovascular disease and is thought to be related to psychological issues. Yet, it is unclear what causes high blood pressure and what causes anxiety, depressive symptoms, neuroticism, and subjective well-being. Aim: Anxiety, depressive symptoms, neuroticism, and subjective well-being were all examined in the current investigation to determine whether there are genetic causes for these conditions. Methods: Eight large-scale genome-wide association study datasets for hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure, anxiety, depressive symptoms, neuroticism, and subjective well-being were subjected to Mendelian randomization (MR) analyses using the generalized retrospective MR analysis method. Results: The multimodal causal link for both blood pressure and the four psychological functioning was found to have a causal effect of DBP on neuroticism, and 1074 independent instrumental single nucleotide polymorphisms were discovered by the incorporated Heterogeneity in Dependent Instruments-outlier test. Conclusion: Neuroticism is a direct causative result of DBP. Proper blood pressure control may lessen neuroticism, mood disorders that increase neuroticism, and cardiovascular problems.

High blood pressure , Hypertension, Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Pulse pressure, Anxiety, Depressive symptoms, Neuroticism.

"Investigation on the genetic factors on blood pressure, anxiety, depressive symptoms, psychoticism, and psychological well-being.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 3, page no.h196-h202, March-2023, Available :http://www.jetir.org/papers/JETIR2303732.pdf

"Investigation on the genetic factors on blood pressure, anxiety, depressive symptoms, psychoticism, and psychological well-being.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 3, page no. pph196-h202, March-2023, Available at : http://www.jetir.org/papers/JETIR2303732.pdf