UGC Approved Journal no 63975(19)

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Volume 10 Issue 3
March-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2303808


Registration ID:
510953

Page Number

i47-i53

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Title

A REVIEW ON HEREDITARY DISEASE : DOWN SYNDROME

Abstract

Down syndrome (DS) is a birth disorder with large medical and social costs, resulting from trisomy of entire or a part of chromosome 21. It is the most typical genetic disorder international and the common genetic cause of intellectual disabilities appearing in about 1 in 400-1500 newborns. Although the syndrome had been described thousands of years before, it was named after John Langdon Down who described its clinical description in 1866. Scientists have diagnosed candidate genes which are involved in the formation of specific DS functions. These advances in turn may assist to develop targeted therapy for persons with trisomy 21. Screening for DS is a crucial a part of routine prenatal care. Down syndrome (DS) is one of the extra commonly occurring genetic disorders, wherein mental retardation is mixed with nutritional diseases. It is resulting from having a 3rd copy of chromosome 21, and there exist three forms; Simple Trisomy 21, Translocation Trisomy and Mosaic Trisomy. Symptoms include intellectual disability/mental retardation, early onset of Alzheimer’s disorder and the appearance of numerous phenotypic functions including narrow slanted eyes, flat nose and short stature. In addition, there are different health troubles during the body, consisting in a part of cardiac defects and thyroid function abnormalities along with nutritional disorders (i.e. overweight, obesity, hypercholesterolemia and deficiencies of nutrients and minerals). Those suffering DS have large body abnormalities and impaired brain development and function; the latter leading to impaired intellectual improvement. Many researches indicate excessive or deficient nutrient uptakes associated with making beside the point foodstuff choices, food intolerance, (e.g. celiac disease) or malabsorption.

Key Words

Down Syndrome, Hereditary disease, DNA sequence, Chromosome 21, Fertility, Epilepsy, Thyroid disorder.

Cite This Article

"A REVIEW ON HEREDITARY DISEASE : DOWN SYNDROME", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 3, page no.i47-i53, March-2023, Available :http://www.jetir.org/papers/JETIR2303808.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"A REVIEW ON HEREDITARY DISEASE : DOWN SYNDROME", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 3, page no. ppi47-i53, March-2023, Available at : http://www.jetir.org/papers/JETIR2303808.pdf

Publication Details

Published Paper ID: JETIR2303808
Registration ID: 510953
Published In: Volume 10 | Issue 3 | Year March-2023
DOI (Digital Object Identifier):
Page No: i47-i53
Country: Jalna, Maharashtra, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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