• Prem Samundre
• Pratima Mishra
• Praveen Tahilani
• Sarika Shrivastava
• Jitendra Banweer

Trans-dermal drug delivery systems (TDDS) can be defined as self- contained discrete dosage forms which, when applied to the intact skin, delivers the drug(s) through the skin at a controlled rate to the systemic circulation. The potential of using intact skin as the route of drug administration has been known for several years. The inspiration of using skin for delivery of drug is from ancient time. Historically, the medicated plaster can be viewed as the first development of trans-dermal drug delivery; this medicated plaster became very popular in Japan as over the counter pharmaceutical dosage form. The present work shows that microemulsion is promising transdermal drug delivery vehicle and enhance the solubility of levofloxacin was done by using this approach. Microemulgel appears better and effective drug delivery system as compared to other conventional topical drug delivery system. Levofloxacin and Diclofenac sodium was successfully formulated in the form of microemulgel by using poly unsaturated fatty acid i.e., Neem oil with Carbopol as gelling agent. Micro- emulsions were prepared by varying Tween 80 and Span 20 concentration in four emulsions. The formulated microemulgel were undergone few evaluation tests to obtain the best optimized formulation to formulate microemulgel by incorporating the optimized formulation in 2%w/w Carbopol gel.

Transdermal Drug Delivery System, Microemulgel, Carbopol, Diclofenac, Tween 80.

"FORMULATION AND DEVELOPMENT OF LEVOFLOXACIN & DICLOFENAC FORMULATION LOADED MICROEMULGEL FOR THE TREATMENT OF BACTERIAL INFECTION BY TRANSDERMAL ROUTE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.b7-b32, August-2023, Available :http://www.jetir.org/papers/JETIR2308102.pdf

"FORMULATION AND DEVELOPMENT OF LEVOFLOXACIN & DICLOFENAC FORMULATION LOADED MICROEMULGEL FOR THE TREATMENT OF BACTERIAL INFECTION BY TRANSDERMAL ROUTE.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppb7-b32, August-2023, Available at : http://www.jetir.org/papers/JETIR2308102.pdf