• Deepika Verma
• Kumud Upadhyaya

Parkinson's disease (PD) is a debilitating and progressive neurodegenerative disorder that primarily targets the motor system. It is characterized by the gradual loss of dopaminergic neurons in the substantia nigra region of the brain, resulting in a wide array of motor and non-motor symptoms. In recent years, significant advancements in PD research have deepened our understanding of its pathogenesis and provided insights into potential therapeutic targets. The accumulation of alpha-synuclein protein aggregates (Lewy bodies) in dopaminergic neurons is considered a key pathological hallmark of PD. This, along with mitochondrial dysfunction, oxidative stress, and inflammation, contributes to the progressive degeneration of dopaminergic neurons. In recent years, there has been a growing interest and shift towards herbal drugs and natural remedies as an alternative or complementary approach to conventional allopathic drugs. Herbal drugs, also known as herbal medicines or phototherapeutics, are derived from plant sources and have been used for centuries in traditional medicine systems worldwide. Plants like Curcuma (turmeric), Withania somnifera (ashwagandha), Trifolium (red clover), and Tripterygium (thunder god vine) are among the many botanicals that have gained attention for their potential therapeutic properties. Curcuma, for example, contains the active compound curcumin, known for its anti-inflammatory and antioxidant properties. Withania somnifera, commonly known as ashwagandha, has been studied for its adaptogenic and stress-reducing effects. Trifolium, or red clover, is rich in phytoestrogens and has been explored for its potential benefits in managing menopausal symptoms. Tripterygium has been investigated for its immunosuppressive properties and its potential in the treatment of autoimmune diseases.

Parkinson's disease (PD), dopaminergic neurons, herbal drugs, Curcuma,

"A Comprehensive Review of Parkinson's Disease: Insights into Pathogenesis, Clinical Features, and Herbal Treatment Strategies", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 8, page no.c542-c550, August-2023, Available :http://www.jetir.org/papers/JETIR2308263.pdf

"A Comprehensive Review of Parkinson's Disease: Insights into Pathogenesis, Clinical Features, and Herbal Treatment Strategies", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 8, page no. ppc542-c550, August-2023, Available at : http://www.jetir.org/papers/JETIR2308263.pdf