UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Volume 10 Issue 11
November-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2311170


Registration ID:
527571

Page Number

b603-b608

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Title

An overview of solubility of Class-2 drugs by FTIR analysis

Abstract

The aim of the present work is to study the solubility of class-2 drugs by FTIR analysis. Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA. Avanafil is sold under the brand names Stendra and Spedra. Avanafil is a class 2 drug. Class 2 drug are Low Solubility and High Permeability Solubility of Pure drug is studied with various Excipients. Alteration of solubility is observed by using FTIR analysis and solubility studies. Higher amino acids are insoluble in water. Avanafil contains more number of amine groups which in turn increases the molar mass of the compound therefore it is low soluble in water. The obtained results indicate that the solubility of class-2 drug i.e AVANAFIL was enhanced when it is mixed with the Excipient Co-Povidine. The Co-Povidine reacts with Avanafil alters the higher amines in Avanafil which increases the polarity of the drug. Co-Povidine also converts the alkenes present in Avanafil which enhances the solubility.

Key Words

Avanafil, Solubility, Co-Povidine, Class -2 Drugs

Cite This Article

"An overview of solubility of Class-2 drugs by FTIR analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.b603-b608, November-2023, Available :http://www.jetir.org/papers/JETIR2311170.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"An overview of solubility of Class-2 drugs by FTIR analysis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppb603-b608, November-2023, Available at : http://www.jetir.org/papers/JETIR2311170.pdf

Publication Details

Published Paper ID: JETIR2311170
Registration ID: 527571
Published In: Volume 10 | Issue 11 | Year November-2023
DOI (Digital Object Identifier):
Page No: b603-b608
Country: Vijayanagaram, Andhrapradesh, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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