UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
Call for Paper
Volume 11 | Issue 10 | October 2024

JETIREXPLORE- Search Thousands of research papers



WhatsApp Contact
Click Here

Published in:

Volume 10 Issue 11
November-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

7.95 impact factor calculated by Google scholar

Unique Identifier

Published Paper ID:
JETIR2311186


Registration ID:
527687

Page Number

b712-b718

Share This Article


Jetir RMS

Title

EFFECT OF Cynodon dactylon, ON METHYL MERCURY-an ENVIRONMENTAL POLLUTANT INDUCED NEUROTOXICITY

Abstract

Methylmercury (MeHg) is highly toxic, and its principal target tissue in human is the nervous system, which has made MeHg intoxication a public health concern for many decades. Cynodon dactylon (Poacae) (CD) is a well-known traditional plant used as a folk remedy in treatment of many symptoms and diseases. The present study was designed to evaluate the effect of CD ethanolic seed extract (EECD) on MeHg-induced neurotoxicity in cerebellum of rats. Phytochemical screening was done to identify the presence of alkaloids and Flavanoids. The phyto chemical screening which had a high level of phenols and amino acids. This is further confirmed by the FT-IR profile which shows the peak at the specific functional groups. Male Wistar rats were administered with MeHg orally at a dose of 5 mg/kg b.w. for 21 days. Experimental rats were given MeHg and also administered with EECD (750 mg/kg, orally) 1 hr prior to the administration of MeHg for 21 days. After MeHg exposure, we observed that activities of catalase, superoxide dismutase, glutathione (GSH) peroxidase, and the level of GSH were reduced. Behavioral changes such as, decreased motor activity, and spatial short-term memory were noted down during MeHg exposure. EECD pre-treatment offered protection from these behavioral changes. These observations highlighted that EECD has a protective effect against MeHg-induced neurotoxicity.

Key Words

Methylmercury, Cynodon dactylon, Cerebellum, Behavioral, FT-IR

Cite This Article

"EFFECT OF Cynodon dactylon, ON METHYL MERCURY-an ENVIRONMENTAL POLLUTANT INDUCED NEUROTOXICITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.b712-b718, November-2023, Available :http://www.jetir.org/papers/JETIR2311186.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"EFFECT OF Cynodon dactylon, ON METHYL MERCURY-an ENVIRONMENTAL POLLUTANT INDUCED NEUROTOXICITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppb712-b718, November-2023, Available at : http://www.jetir.org/papers/JETIR2311186.pdf

Publication Details

Published Paper ID: JETIR2311186
Registration ID: 527687
Published In: Volume 10 | Issue 11 | Year November-2023
DOI (Digital Object Identifier):
Page No: b712-b718
Country: TIRUNELVELI, TAMILNADU, India .
Area: Medical Science
ISSN Number: 2349-5162
Publisher: IJ Publication


Preview This Article


Downlaod

Click here for Article Preview

Download PDF

Downloads

00082

Print This Page

Current Call For Paper

Jetir RMS