• Karishma Joshi
• Santoshi Shah
• Dr. Shivanand Patil

Mometsone furoate is a corticosteroid (glucocorticoid) having an anti-inflammatory activity. Corticosteroids showed a wide range of effects on various cell types such as mast cells, eosinoplills, neutrophills, macrophages, and lymphocytes. A validated stability-indicating method has been developed for the simultaneous determination of mometsone furoate (MOM) and salicylic acid (SAA) in a combined dosage form. This method is based on the reversed-phase high performance liquid chromatographic (HPLC) separation of the cited drugs. The calibration graphs for each drug were rectilinear in the range of 0.25–15 and 12.5–750 mg mL1 for MOM and SAA, respectively using dexamethasone acetate as the internal standard. The proposed HPLC-DAD method was successfully applied in the determination of the investigated drugs in ointment. The method was validated in compliance with ICH guidelines, in terms of linearity, accuracy, precision, robustness, limits of detection and quantitation and specificity.

Mometsone Furoate, Salicylic Acid, HPLC-DAD

"DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MOMETASONE FUROATE TOPICAL FORMULATION BY HPLC-DAD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.p370-p382, May-2024, Available :http://www.jetir.org/papers/JETIR2405G51.pdf

"DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF MOMETASONE FUROATE TOPICAL FORMULATION BY HPLC-DAD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppp370-p382, May-2024, Available at : http://www.jetir.org/papers/JETIR2405G51.pdf