• Ms. Pooja A. Karpe
• Mr. Sachin Bhausaheb Wagh
• Dr. V.P.Patil
• Dr. S.S. Angadi

Diabetes mellitus is a type of chronic metabolic disorder categorized by insufficiency in insulin activity and/or insulin secretion with multiple etiologies, defined by problems in the metabolism of proteins, lipids, and carbohydrates as well as consistently elevated blood sugar levels. With a variety of treatment options, most people with type 2 diabetes still struggle to reach their glycaemic targets, and their disease gets worse if left untreated. Current euglycemia treatments frequently have negative side effects. However, traditional medicinal herbs have strong antidiabetic properties, improving metabolic pathways without having negative side effects. Wood apple, or "kaitha," is another name for Limonia acidissima, one of the numerous easily accessible therapeutic herbs. According to preliminary , L. acidissima fruit ethanolic extract may have antidiabetic effects. The goal of this study was to determine the methanolic extract of Limonia acidissima (MELA) leaves' graded-dose antidiabetic activity in rats. Methods and Materials: Eight male Wistar rats were randomly assigned to one of six groups: normal control, diabetic control (alloxan-induced), or test groups, in which different dosages of MELA (100 mg/kg, 200 mg/kg, and 400 mg/kg) or Metformin (100 mg/kg) were given after alloxan induction. Throughout the course of 28 days, random blood sugar (RBS) levels were assessed at predetermined intervals. Conclusion: The results of our study indicated that MELA had strong, dose-dependent antidiabetic effects.

Diabetes mellitus, Limonia acidissima, medicinal herbs, methanolic extract, experimental studies.

""Exploring the Anti-Diabetic Potential of Limonia acidissima: A Comprehensive Review of In-Vivo Studies and Therapeutic Insights"", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 1, page no.b727-b739, January-2025, Available :http://www.jetir.org/papers/JETIR2501196.pdf

""Exploring the Anti-Diabetic Potential of Limonia acidissima: A Comprehensive Review of In-Vivo Studies and Therapeutic Insights"", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 1, page no. ppb727-b739, January-2025, Available at : http://www.jetir.org/papers/JETIR2501196.pdf