• PUSHPESH MALLIK
• Shivani Rangarh
• Aditya Garg
• Akshat pratap singh

Luliconazole nanosomal gels signify a significant breakthrough in topical antifungal treatment, providing superior drug absorption, better retention, and extended antifungal efficacy compared to standard formulations. This review examines the formulation and characterization of a luliconazole nanosomal gel that includes tea tree oil, castor oil, and clove oil, which act as permeation enhancers and antimicrobial agents. The formulation process entails selecting lipid-based carriers, excipients, and optimal preparation methods to ensure stability and effectiveness. The characterization of the nanosomal gel encompasses assessments of physical appearance, viscosity, pH levels, and in vitro release studies, which together ascertain its structural integrity and drug release performance. The antifungal efficacy of the formulation is assessed through minimum inhibitory concentration (MIC) and zone of inhibition tests, validating its therapeutic potential against dermatophytid infections. Furthermore, skin permeation studies and cytotoxicity evaluations confirm its safety and efficacy in transdermal drug delivery. Clinical implications underscore its benefits over conventional formulations in enhancing bioavailability and therapeutic results. Future efforts will concentrate on refining formulation parameters, executing large-scale clinical trials, and addressing regulatory issues to promote commercialization. In summary, this cutting-edge nanosomal gel system exhibits considerable promise for improved antifungal therapy, with encouraging market prospects in dermatology.

Luliconazole, Nanosomal gel, Antifungal formulation, Topical drug delivery, Natural oils in pharmaceuticals, Skin permeation enhancers

"Development and assessment of luliconazole nanosomal gel with natural oil ( tea tree oil, clove oil ,castor oil)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 4, page no.l243-l257, April-2025, Available :http://www.jetir.org/papers/JETIR2504B29.pdf

"Development and assessment of luliconazole nanosomal gel with natural oil ( tea tree oil, clove oil ,castor oil)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 4, page no. ppl243-l257, April-2025, Available at : http://www.jetir.org/papers/JETIR2504B29.pdf