• Chandralekha
• Parthiban
• Margaret Beula
• Sundaram Ravikumar
• Banergee Rajkumar

In recent times, the marine plants, especially, the seaweeds are considered as one of the potential raw materials in the preparation of drugs to treat infectious diseases. In the present study an attempt is also made to isolate the unique chemical classes from the ethanolic crude extract of Caulerpa sealpelliformis by sequential extraction by column chromatography and identified by MASS , FTIR 13C NMR and 1H NMR spectroscopic techniques. Phenanthrenol derivatives and N-(2-hydroxy-1-hydroxymethyl octadec-3-enyl)-propionamide have been isolated. In order to develop an antimalarial drug from the seaweed which are known to have potentiality in the malarial infected treatment, the present study has been taken up. The in-vitro antiplasmodial activity of the isolated compounds viz.,N-(2-Hydroxy-1-hydroxymethyloctadec-3-enyl)-propionamide and Phenanthrenol derivative were assessed against P. falciparum and the IC50values which falls under the active category as they fall in the range IC50< 5 to < 50 µg ml−1. Thus, it has maximum inhibition of parasitemia for the treatment of malaria.

Caulerpa sealpelliformis, P. falciparum, MASS , FTIR 13C NMR and 1H NMR

"Antimalarial activity of identified chemical classes of Caulerpa scalpelliformis from Tuticorin coast against chloroquinone sensitive Plasmodium falciparum", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.1089-1095, February-2019, Available :http://www.jetir.org/papers/JETIRAB06203.pdf

"Antimalarial activity of identified chemical classes of Caulerpa scalpelliformis from Tuticorin coast against chloroquinone sensitive Plasmodium falciparum", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp1089-1095, February-2019, Available at : http://www.jetir.org/papers/JETIRAB06203.pdf