• SWETA THAKUR
• SUMAN KUMARI

Amyotrophic lateral sclerosis is a disorder especially affecting motor neuron and generally characterized by degeneration of upper and lower motor neuron. It even leads to death within 3 to 5 years causing respiratory failure. There are number of factors which are responsible for causing a neuron disease. It mainly affects older age group i.e. above 60 years. Men are highly at risk as compared to women. The overall ratio is about 1.5 men to every woman. The clinical history of the patients helps in diagnosis. Primarily it affects the control muscles which we needed to speak, move, eat and breathe. In this review the diagnosis, pathogenicity, therapies, current scenario has been discussed. The understanding of pathological physiology of ALS will help in development of rapid and improved diagnostic tools and effective therapies for recovery. This review will help the readers and scientist to gain broad information regarding ALS disease.

Amyotrophic lateral sclerosis, Neurodegeneration, Familial type ALS, Paralysis

"Amyotrophic Lateral Sclerosis: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 11, page no.937-944, November 2018, Available :http://www.jetir.org/papers/JETIRDS06140.pdf

"Amyotrophic Lateral Sclerosis: A Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 11, page no. pp937-944, November 2018, Available at : http://www.jetir.org/papers/JETIRDS06140.pdf