• Gurinder Rana
• Sandeep Sharma

Colistin drug is used as last line of drug for the treatment of gram-negative bacterial infection which is the main cause of morbidity and mortality. These life-threatening bacteria are on the peak priority list of World Health Organization, carbapenem resistant bacteria. E. coli, pseudomonas and Acinetobacter baumannii. Colistin is used to treatment of multi-drug resistant gram-negative bacteria but the colistin resistance has been occurred. This review contains information of recent research papers in last five years from 2016-2020. Genes involved in the mechanism of colistin resistance are pmrA/pmrB, phoP/phoQ, arnBCDTEF, mcr1-mcr5, mcr7, mcr8 and many other genes. There are various methods used to know the mechanism of resistance like antibiotic susceptibility test, agar dilution method, Quantitative RT-PCR, Transposon mutant technique and MALDI-TOF MX. So, the combinational therapy, triple vaccination, bacteriophages and monoclonal therapies could be useful for treatment.

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"Review on Colistin resistance among gram-negative bacteria (2016-2020)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.1393-1396, January 2019, Available :http://www.jetir.org/papers/JETIRDY06222.pdf

"Review on Colistin resistance among gram-negative bacteria (2016-2020)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp1393-1396, January 2019, Available at : http://www.jetir.org/papers/JETIRDY06222.pdf