• Avdhesh Kumar Yadav

The early cognitive performance of children born to mothers with epilepsy (n = 198) has been tested in this longitudinal analysis and compared to a group of children comprising the general population (n = 230). Children were evaluated using the Griffiths Mental Development Scales at a younger age than 2 years, either in their local participating hospital or in their home. An evaluator who was blinded to whether the mother of the boy had seizures as to the type of antiepileptic treatment performed the tests. Children exposed to sodium valproate had a statistically significant elevated risk of delayed early growth in contrast to the control children. Linear regression research revealed a statistically meaningful impact of sodium valproate toxicity on the child’s average developmental stage that was not compensated for by confounding variables. For children within an ad hoc group of less widely used antiepileptic medications, delayed early development is also observed, but conclusions should not be made because of the size of this group (n = 13). In children exposed to either carbamazepine or lamotrigine in utero, their overall developmental ability did not differ significantly. Differences observed in particular developmental areas for these two classes were not statistically important after the control for confounders such as social status and maternal IQ. Women with epilepsy should be aware of the dangers present to their future offspring prior to birth to allow for informed choices about treatment. Throughout infancy, infants subjected in utero to antiepileptic medications should be controlled to allow for early intervention if appropriate.

Carbamazepine (CBZ), Sodium Valproate (VPA), lamotrigine (LTG), Polytherapy Treatments.

"A Paper on Cognitive Development in Children", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.265-267, January 2019, Available :http://www.jetir.org/papers/JETIREO06057.pdf

"A Paper on Cognitive Development in Children", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp265-267, January 2019, Available at : http://www.jetir.org/papers/JETIREO06057.pdf