UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 9 Issue 10
October-2022
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRFU06043


Registration ID:
505188

Page Number

353-357

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Title

SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLES AS USEFUL LEADS TOWARDS THE DEVELOPMENT OF POTENT ANTIMICROBIAL AGENTS

Abstract

The chemical structures of the produced products were determined by the analysis of their IR, 1H NMR, and 13C NMR spectra and the detection of their physicochemical attributes. We used the agar dilution technique to test the antibacterial efficacy of coumacines in vitro against a panel of typical aerobic and anaerobic bacterial strains, with ciprofloxacin and metronidazole serving as positive controls. From what can be seen in the data, compounds 1–12 had only moderate antibacterial efficacy against the strains used in the tests, with compound 12 showing the most promise. The MIC values against S for all of these drugs ranged from 32 to 64 lg/ml. E. bovis E. coli and Klebsiella pneumoniae. Except for compound 12, which had a MIC of 16 µg/ml against all strains of T. tropicalis tested, all other compounds showed no activity. These chemicals were tested for their minimum inhibitory concentrations (MICs) against S. aureus and P. aeruginosa biofilms. mutans were found to be between 64 and 256 µg/ml and 64 and 128 µg/ml, respectively, which appears high, leading one to the conclusion that these compounds have enormous potential to be used as a two in one formulation of antibacterial and antifungal agents.

Key Words

Heterocyclic compounds, Antifungal activity, Antibacterial, Thiazoles, Pyrazoline

Cite This Article

"SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLES AS USEFUL LEADS TOWARDS THE DEVELOPMENT OF POTENT ANTIMICROBIAL AGENTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.9, Issue 10, page no.353-357, October-2022, Available :http://www.jetir.org/papers/JETIRFU06043.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"SYNTHESIS OF BIOLOGICALLY ACTIVE HETEROCYCLES AS USEFUL LEADS TOWARDS THE DEVELOPMENT OF POTENT ANTIMICROBIAL AGENTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.9, Issue 10, page no. pp353-357, October-2022, Available at : http://www.jetir.org/papers/JETIRFU06043.pdf

Publication Details

Published Paper ID: JETIRFU06043
Registration ID: 505188
Published In: Volume 9 | Issue 10 | Year October-2022
DOI (Digital Object Identifier):
Page No: 353-357
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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