• Vaishnavi B. Rathi
• Barge Jaymala S
• Sabne Anand M.
• Sachin Gholve

To perform an assessment of a commercial tablet formulation, a reverse phase high performance liquid chromatography (RP-HPLC) method was created, verified, and estimated simultaneously to measure the stability of irbesartan and amlodipine in combination dose form at a single wavelength (245nm) (AIMIX Tablet). The orthophoshoric acid buffer was used to develop the isocratic technique on an HPLC hypersil BDS (Shimadzu-LC 20AT) C18 column with 4.6 mm i.d. and 5 m particle size: 1.0 mL/min of chloroform, toluene, methanol, and acetic acid, supplied at ambient temperature (25 oC) and injection volume (20 l), respectively. Amlodipine besylate and irbesrtran both had average peaks of 1477.436 and 3622.950, respectively. The analysis's findings were statistically confirmed in accordance with ICH recommendations. Based on the findings of the linearity range and RSD for intraday precision, the suggested RP-HPLC technique was determined to be sensitive, accurate, precise, simple, and quick. All of the results were satisfactory, demonstrating the method's viability for use in daily quality control and drug testing.

Amloldipine Besylate, Irbesartan, Combined Dosage Form

"“RP-HPLC METHOD DEVELOPMENT AND SIMULTANIUS ESTIMATION OF AMLODIPINE BESYLATE AND IRBESARTAN”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.67-78, April-2023, Available :http://www.jetir.org/papers/JETIRFW06008.pdf

"“RP-HPLC METHOD DEVELOPMENT AND SIMULTANIUS ESTIMATION OF AMLODIPINE BESYLATE AND IRBESARTAN”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp67-78, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06008.pdf