UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 4
April-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRFW06008


Registration ID:
512362

Page Number

67-78

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Title

“RP-HPLC METHOD DEVELOPMENT AND SIMULTANIUS ESTIMATION OF AMLODIPINE BESYLATE AND IRBESARTAN”

Abstract

To perform an assessment of a commercial tablet formulation, a reverse phase high performance liquid chromatography (RP-HPLC) method was created, verified, and estimated simultaneously to measure the stability of irbesartan and amlodipine in combination dose form at a single wavelength (245nm) (AIMIX Tablet). The orthophoshoric acid buffer was used to develop the isocratic technique on an HPLC hypersil BDS (Shimadzu-LC 20AT) C18 column with 4.6 mm i.d. and 5 m particle size: 1.0 mL/min of chloroform, toluene, methanol, and acetic acid, supplied at ambient temperature (25 oC) and injection volume (20 l), respectively. Amlodipine besylate and irbesrtran both had average peaks of 1477.436 and 3622.950, respectively. The analysis's findings were statistically confirmed in accordance with ICH recommendations. Based on the findings of the linearity range and RSD for intraday precision, the suggested RP-HPLC technique was determined to be sensitive, accurate, precise, simple, and quick. All of the results were satisfactory, demonstrating the method's viability for use in daily quality control and drug testing.

Key Words

Amloldipine Besylate, Irbesartan, Combined Dosage Form

Cite This Article

"“RP-HPLC METHOD DEVELOPMENT AND SIMULTANIUS ESTIMATION OF AMLODIPINE BESYLATE AND IRBESARTAN”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.67-78, April-2023, Available :http://www.jetir.org/papers/JETIRFW06008.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"“RP-HPLC METHOD DEVELOPMENT AND SIMULTANIUS ESTIMATION OF AMLODIPINE BESYLATE AND IRBESARTAN”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp67-78, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06008.pdf

Publication Details

Published Paper ID: JETIRFW06008
Registration ID: 512362
Published In: Volume 10 | Issue 4 | Year April-2023
DOI (Digital Object Identifier):
Page No: 67-78
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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