• Samiksha Kadu
• Sneha Jadhav
• Shivani Biradar
• Anant Deshpande

One of the most glaringly varied phenotypes in humans is hyperpigmentation disorders, which are frequent in the Indian population. It is well recognised that pigmentation disorders can be exacerbated or brought on by UV light exposure. Tyrosinase inhibitors can be useful tools in the cosmetics and pharmaceutical sectors since they are involved in the manufacture and control of melanin. In the last five years, chalcones, hydroxystilbenes, thiosemicarbazones, and lignans have been identified in the literature as the most effective tyrosinase inhibitors among the most often used scaffold, flavonoids. According to a number of published inhibition mechanisms, the inhibitors discussed here must contain copper chelating and/or hydrophobic moieties in order to have effective inhibition capabilities. In the current study, however, 18 derivatives of the 2-Phenyl chromane scaffold were subjected to in silico studies using Pass online, Mol Inspiration, Pro Tox II, and IGEMDOCK to investigate their in vitro inhibitory effect against mushroom tyrosinase. In silico docking studies with mushroom tyrosinase (PDB ID 2Y9X) predicted that these compounds would interact with the active site of mushroom tyrosinase. The findings highlighted the significance of the flavonoid core with a hydroxyl group at C-7 as a significant contributor to tyrosinase inhibitory activity. These compounds could form metal-ligand interactions with the Cu2+ ions in the active site, according to the docked conformations. As a result, the in silico results served as a template for subsequent synthesis, in vitro, and in vivo studies to obtain promising mushroom tyrosinase inhibitors.

In silico approach, Tyrosinase, 2-Phenyl chromane

"DESIGN OF SOME 2-PHENYL CHROMANE DERIVATIVES AS NEW POTENTIAL TYROSINASE INHIBITORS BY IN SILICO APPORACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.231-244, April-2023, Available :http://www.jetir.org/papers/JETIRFW06031.pdf

"DESIGN OF SOME 2-PHENYL CHROMANE DERIVATIVES AS NEW POTENTIAL TYROSINASE INHIBITORS BY IN SILICO APPORACH", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp231-244, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06031.pdf