• Narendra P. Surse
• Amol D. Kale
• Ram Khalapure
• Bharat. K. Dhotre

A rapid and efficient method for the one-pot synthesis of unsymmetrical 2,5- disubstituted 1,3,4-oxadiazoles has been developed using 2,4-difluorobenzohydrazide with substituted benzoic acid in presence in the presence of phosphorus oxychloride as a catalyst under ultrasonic irradiation with silica-supported. A wide variety of aromatic 2,4-difluorobenzohydrazide as well as substituted benzoic acid exhibit oxidative cyclization to yield corresponding unsymmetrical 2,5- disubstituted 1,3,4-oxadiazoles. The structures of these compounds are elucidated by their spectral data (IR, 1H NMR, and MS). Maximum Yield, Short reaction time, and use of Silica and Ultrasonic are merits of the developed protocol.

One Pot, ultrasonic irradiation, Silica, 1,3,4- oxadiazoles, 2,4- difluorobenzohydrazide

"“One pot Synthesis 1,3,4-oxadiazole Derivatives Under under ultrasonic irradiation with silica-supported ”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.422-427, April-2023, Available :http://www.jetir.org/papers/JETIRFW06055.pdf

"“One pot Synthesis 1,3,4-oxadiazole Derivatives Under under ultrasonic irradiation with silica-supported ”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp422-427, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06055.pdf