UGC Approved Journal no 63975(19)

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Published in:

Volume 10 Issue 4
April-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIRFW06076


Registration ID:
512280

Page Number

561-567

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Title

AN OVERVIEW OF NOVEL DRUG DELIVERY SYSTEMS FOR NSAIDS IN THE TREATMENT OF RHEUMATOID ARTHRITIS

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease that causes chronic joint inflammation, resulting in severe disability and premature death. It has a global prevalence of around 1%, with women being affected 2-3 times more than men. The pathogenesis of the disease involves preclinical RA, genetic factors, and environmental factors. The RA has no known cure and the primary aim of treatment remains to attain lowest possible disease activity and recovery if possible. The present review highlights the literature on the different treatment options available for the treatment of RA, their mechanisms of action, side effects, and novel drug delivery systems that are in use for drug administration with the main focus on novel drug delivery systems of non-steroidal anti-inflammatory drugs. Different drug classes are discussed, including corticosteroids, NSAIDs, DMARDs, and biologics, with examples of the most commonly used drugs in each class. Many disadvantages of conventional drug therapy include low solubility and permeability, poor bioavailability, degradation by gastrointestinal enzymes, first pass metabolism, food interactions, and toxicity. Novel drug delivery systems such as microspheres, nanoparticles, cubosomes, liposomes, ethosomes and so on are promising tools because they have overcome the drawbacks of traditional drug delivery systems. The current review squares the various novel drug delivery systems that have been investigated for the administration of anti-rheumatic drugs.

Key Words

AN OVERVIEW OF NOVEL DRUG DELIVERY SYSTEMS FOR NSAIDS IN THE TREATMENT OF RHEUMATOID ARTHRITIS

Cite This Article

"AN OVERVIEW OF NOVEL DRUG DELIVERY SYSTEMS FOR NSAIDS IN THE TREATMENT OF RHEUMATOID ARTHRITIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 4, page no.561-567, April-2023, Available :http://www.jetir.org/papers/JETIRFW06076.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"AN OVERVIEW OF NOVEL DRUG DELIVERY SYSTEMS FOR NSAIDS IN THE TREATMENT OF RHEUMATOID ARTHRITIS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 4, page no. pp561-567, April-2023, Available at : http://www.jetir.org/papers/JETIRFW06076.pdf

Publication Details

Published Paper ID: JETIRFW06076
Registration ID: 512280
Published In: Volume 10 | Issue 4 | Year April-2023
DOI (Digital Object Identifier):
Page No: 561-567
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication


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