• MAYANK RAI
• RAJESH GOUR
• AKHLESH KUMAR SINGHAI

Gastroretentive Drug Delivery Systems (GRDDS) present a promising approach to enhance the bioavailability and therapeutic efficacy of orally administered drugs, particularly those with narrow absorption windows or low solubility. This innovative drug delivery system aims to prolong gastric residence time, thereby optimizing drug release and absorption. By leveraging various formulation strategies such as floating systems, mucoadhesive systems, and expandable systems, GRDDS ensures sustained drug release and improved patient compliance. This abstract provides an overview of GRDDS, including its rationale, design principles, formulation approaches, and potential applications in pharmaceutical research and development. Furthermore, it discusses the advantages, challenges, and future perspectives of GRDDS, highlighting its significant impact on the advancement of oral drug delivery technology.

Introduction, Importance, Floating Systems, Bioadhesive Systems, Swelling and Expanding Systems, High-Density Systems, Drug Release Kinetics, Mucoadhesive Systems, Expandable Systems, Treatment of Gastric Ulcers, Controlled Release of Drugs, Safety and Tolerability, Patient Compliance, Regulatory Perspectives.

"GASTRO-RETENTIVE DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.a142-a152, May-2024, Available :http://www.jetir.org/papers/JETIR2405019.pdf

"GASTRO-RETENTIVE DRUG DELIVERY SYSTEM", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppa142-a152, May-2024, Available at : http://www.jetir.org/papers/JETIR2405019.pdf