• Veldandi Saritha

ABSTRACT The developed technique's analytical approach validation document is produced. Method development, optimization of mass parameters, optimization of chromatographic parameters, optimization of extraction methods, selection of a regression version, optimization of sensitivity, recovery, and balance parameters, and so on. In the system of technique validation, selectivity, specificity, sensitivity, intra-inter assay precision and accuracy, recuperation, and stability parameters consisting of vehicle sampler stability, room temperature stability, freeze-thaw balance, and reinjection balance should be confirmed. There is a demand to illustrate the utility of pharmaceutical formulations in organic samples following the improvement and validation of selected capsules' methods. Tenofovir is one of the newer, more tolerable, nucleotide reverse transcriptase inhibitors on the market; is a mainstay of many antiretroviral therapy combinations; and is now available in 2 different formulations, tenofovir disoproxil fumarate (TDF) and, the more recent, tenofovir This manuscript provides insight into the history of TDF development, their unique pharmacokinetics and pharmacology, clinically important adverse effects, monitoring, interactions, resistance, review of clinical studies, and guideline recommendations and clinical applications for tenofovir’s various indications.

KEYWORDS: Method development, Validation, Antiviral, drugs, RP-HPLC,

"A STUDY ON DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ANTIVIRAL DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 1, page no.g387-g394, January-2024, Available :http://www.jetir.org/papers/JETIR2401646.pdf

"A STUDY ON DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR ANTIVIRAL DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 1, page no. ppg387-g394, January-2024, Available at : http://www.jetir.org/papers/JETIR2401646.pdf