• Sharath N
• Jyothi K
• Chanrashekara Raje Urs H R

Abstract A versatile method was adopted for the synthesis of isoxazole and its derivatives by using click chemistry. Isoxazole is further condensed with the ethylene-di-amine to obtain new bis-isoxazole moieties and characterized by IR, 1H NMR and mass spectra. These derivatives were auxiliaryly screened for antibacterial activity with succession of gram positive and gram negative bacteria which exhibited good results. The photo induced cleavage studies at 360 nm, exposed that the compounds possess photonuclease property against pUC19 DNA without inhibitors.

Antibacterial, inhibitors, isoxazole, DNA photocleavage activity.

"DNA PHOTOCLEAVAGE AND ANTIMICROBIAL STUDIES ON NEW ISOXAZOLE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.361-371, May-2019, Available :http://www.jetir.org/papers/JETIR1905154.pdf

"DNA PHOTOCLEAVAGE AND ANTIMICROBIAL STUDIES ON NEW ISOXAZOLE DERIVATIVES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp361-371, May-2019, Available at : http://www.jetir.org/papers/JETIR1905154.pdf