• Chandra Prakash Maurya
• Mr. Sagar Bansal*
• Mrs. Rajbala Singh
• Dr. Arvind Kumar Srivastava

Poor aqueous solubility remains one of the most significant challenges in modern drug development, limiting the bioavailability and therapeutic effectiveness of many promising drug candidates. Solid dispersion is a formulation strategy designed to address this issue by dispersing poorly water-soluble drugs in an inert carrier matrix, thereby enhancing their dissolution rate and solubility. This review aims to provide a comprehensive discussion on solid dispersion technology, covering the various preparation techniques, underlying mechanisms of solubility enhancement, types of carriers employed, and the advantages offered by this approach, such as improved bioavailability and dose reduction. Additionally, it examines key limitations, including physical instability and scale-up challenges, while also exploring future prospects and emerging trends in the field that hold promise for overcoming these barriers and advancing pharmaceutical development.

Solid dispersion, solubility enhancement, amorphous systems, pharmaceutical technology, drug delivery

"Solid Dispersion Techniques for Solubility Enhancement: A Comprehensive Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.12, Issue 6, page no.i318-i327, June-2025, Available :http://www.jetir.org/papers/JETIR2506842.pdf

"Solid Dispersion Techniques for Solubility Enhancement: A Comprehensive Review", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.12, Issue 6, page no. ppi318-i327, June-2025, Available at : http://www.jetir.org/papers/JETIR2506842.pdf