• Dr. Sushma Singh
• Dhanik Patel
• Malavika Shylajan

In the work undertaken, an attempt has been made to formulate and evaluate fast-dissolving oral films (FDOFs) of Ivabradine hydrochloride to have a rapid onset of action with increased bioavailability and improved patient compliance. FODFs were fabricated by solvent casting technique. Various film formers, Hydroxypropyl Methylcellulose (HPMC) of different viscosity grades, and polyhydric alcohols in various proportions and combinations were explored to optimize the composition of FDOFs. Among all polymers, a combination of HPMC E3 & E5 showed the desired film-forming capacity. The suitable plasticizer and its concentration were selected based on flexibility and tensile strength. Flexible films were obtained by using 20% w/w glycerin. Nine batches of films with the drug were prepared by varying concentrations of polymers and the resultant films were evaluated for various physicochemical properties such as weight of film, thickness, tensile strength, folding endurance, surface pH, drug content, in vitro disintegration time, and in vitro dissolution studies, all of which showed satisfactory results. Among all the formulations F4 with a combination of polymers (1:2) showed a maximum release of 96 % within 210 seconds, with a mean disintegration time of 15 seconds emerging to be the ideal formulation. The optimum film composition was also tested in vivo for film palatability in human volunteers and the results revealed that there was no bitter taste, no irritation, and a good mouth feel was observed. Furthermore, the FODFs were stable for at least 2 months when stored at 40°C and 75% relative humidity.

Fast dissolving oral films, Ivabradine hydrochloride, Solvent casting technique, HPMC E3 & E5

"FAST DISSOLVING ORAL FILMS: A NOVEL APPROACH FOR THE DELIVERY OF IVABRADINE HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.e191-e201, May-2024, Available :http://www.jetir.org/papers/JETIR2405423.pdf

"FAST DISSOLVING ORAL FILMS: A NOVEL APPROACH FOR THE DELIVERY OF IVABRADINE HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppe191-e201, May-2024, Available at : http://www.jetir.org/papers/JETIR2405423.pdf