• Vikas Dashrath Sonawane

A novel method for the synthesis of Methoxy chromone chalcones (4a-i) have been introduced via Claisen-Schmidt synthesis by using recyclable PEG-400 as an alternative reaction medium. Different substituted methoxy chromone chalcones have been carried out by using 3-formyl 6- methoxy chromone and various different substituted tetralones , acetyl benziimidazole and acetyl ferrocene. It highlighten the chemical reactivity of 3-formyl chromones towards the synthesis of chromone chalcones. Bicyclic chromone moiety has been used as a privileged structure in the development of pharmacologically active compounds as scaffolds used as drug in medicinal chemistry. The structures of these compounds were confirmed on the basis of spectral data. Synthesized Novel methoxy Chromone Chalcones were screened for their antimicrobial activities against four pathogenic bacterial strains viz. Bacillus subtilis (Gram-positive), Escherichia coli (Gram-negative), Pseudomonas aeruginosa (gram-negative), Staphylococcus aureus (Gram-positive) and various antibiotics like Gentamicin, amoxycilin and streptomycin. Evaluation of the inhibitory influence of pathogenic bacterial growth of the synthesized methoxy chromone chalcones (4a-i) was carried out by Agar diffusion method. Their minimum inhibitory concentrations (MIC) were determined and the compounds 4d, 4f, 4g 4h and 4i shows good results of antimicrobial activity while compound 4a, 4b, 4c and 4e shows mild antimicrobial activity against standard B.subtilis, E.coli, P. aeruginosa and S.aureus bacteria and antibiotics like Gentamicin, amoxycilin and streptomycin.

Chromones, 3- formyl 6- methoxy chromones, Methoxy chromone chalcones, Vilsmeier – Haack reaction, Claisen-Schmidt synthesis , Antimicrobial Activity.

"Design, Synthesis, Spectral Characterization And In Vitro Antimicrobiol Activity Of Novel methoxy Chromone Chalcones", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.538-546, May-2019, Available :http://www.jetir.org/papers/JETIR1905280.pdf

"Design, Synthesis, Spectral Characterization And In Vitro Antimicrobiol Activity Of Novel methoxy Chromone Chalcones", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp538-546, May-2019, Available at : http://www.jetir.org/papers/JETIR1905280.pdf