• Rukmani Patel
• Manish Upadhyay

O-phenylenediamine on condensation with substituted aromatic acids in polyphosphoric acid confer benzimidazole nucleus which over reaction with ethyl chloroacetate. Synthesis of 2-(substituted phenyl)-1H-benzimidazole 3a-d An equiable quantities of o-phenylenediamine 1 (0.05 mol) and substituted benzoic acid 2a-d (0.05 mol) were fluxed in poly phosphoric acid (15 g) and refluxed for 6-9 hrs at 180-185°C with constant exhilarating. The reaction mixtures were chilled and slowly poured into 200 g of crashed ice with constant exhilarating. A novel series of N-(substituted benzylidene)-2-[(2-(substituted phenyl)-1H-benzimidazol-1-yl) acetohydrazide derivatives 6a-l had been synthesized and characterized by IR, NMR, mass and elemental investigation. The final compounds were evaluated for in vitro antibacterial activity across both Gram-positive and Gram-negative strains of bacteria through cup-plate method. Among the different derivative, the compounds 6a-6f great inhibition of bacterial growth as analysed to standard drug ciprofloxacin.

Benzimidazole, Synthesis, Antibacterial Agents.

"SYNTHESIS AND CHARACTERIZATION OF NOVEL ANTIBACTERIAL AGENTS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.384-400, May-2019, Available :http://www.jetir.org/papers/JETIR1905954.pdf

"SYNTHESIS AND CHARACTERIZATION OF NOVEL ANTIBACTERIAL AGENTS ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp384-400, May-2019, Available at : http://www.jetir.org/papers/JETIR1905954.pdf