• ASHMA
• SASIKUMAR. G
• SUBRAMANI.A
• ASKAR ALI

A Ligand (E) –N-Cyclohexyl-2-(1-(5-Bromo thiophen-2-yl) ethylidene) hydrazine carbothioamide was synthesised and characterized by 1H NMR, 13C NMR, FT-IR, UV-Vis spectroscopy and elemental analysis. Cobalt(II),Nickel(II),Copper(II) and Zinc(II) complexes of thiosemicarbazones were characterized by elemental analysis, FT- IR,UV-Vis, EPR and ESI- Mass spectral studies. Ligand (HL) and its metal complexes have been screened in vitro antimicrobial activity against E.Coli,S.aureus,P.aeruginosa,E.facecalis and C.albicans . Further,the ligand and the complexes were docked with dihydrofolate reductase (DHFR).

Thiosemicarbazone; metal complexes; antimicrobial screening; dihydrofolate reductase.

"Molecular Docking and Antimicrobial activity of heterocyclic thiosemicarbazone and their transition metal complexes.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 5, page no.4-14, May-2019, Available :http://www.jetir.org/papers/JETIR1905B02.pdf

"Molecular Docking and Antimicrobial activity of heterocyclic thiosemicarbazone and their transition metal complexes.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 5, page no. pp4-14, May-2019, Available at : http://www.jetir.org/papers/JETIR1905B02.pdf